The technology and knowledge transfer from
university to industry has raised the attention of policy makers and
practitioners as fundamental process in promoting the development of regional
innovation and entrepreneurship. University Spin-Offs (USOs), firms established
to commercialize the knowledge and technology outcomes of academic research,
may constitutes an effective mechanism to improve the innovative dynamics in
the regional area. The paper explores the assumption that USOs may partially
determine the innovation of regions they are located. From a panel sample of 944
USOs placed in 20 Italian administrative regions, the findings remark that USOs
(analysed as  number of USOs from each University and  patents activity
of USOs) has a positive impact on the regional innovation in term of regional
patent applications, while a weak role of USOs seems to emerge in term of
regional expenditure in R&D.
JEL classification numbers: O30,
Spin-Offs, Regional innovation, Entrepreneurial University, Italy.