The objective of this study is to investigate the effect of four corporate entrepreneurship determinants; structure, management, culture and environment on organizational performance of public higher education institutions in Pakistan. Hypotheses were developed to determine the relationships between these determinants and performance of the institutions. Data were collected by means of structured mail survey questionnaires from the 225 faculty deans of the 74 state-owned universities in Pakistan, and multiple regression analysis was conducted to identify the predictive ability of the four determinants as independent variables on organizational performance. The findings reveal positive and significant relationships between management, culture and environment and performance. No significant relationship was found between structure and performance. The findings ultimately enhance the field of corporate entrepreneurship which focuses on improving the performance of the higher education institutions in Pakistan.