Background: The aim of this study was to evaluate the
albumin/globulin (A/G) ratio as a diagnostic marker for relapsing ocular Behçet’s
disease. Methods: This study was conducted using retrospective design.
Patients of ocular Behçet’s disease under infliximab infusion therapy were
registered. The parameters for remission, i.e., total protein, albumin, serum
protein fraction, serum amyloid A (SAA), C reactive protein (CRP), erythrocyte
sedimentation rate (ESR), were monitored. The inflammatory proteins; á1-antitripsine, á1 acid glycoprotein, retinol binding protein,
haptoglobin, ceruloplasmin, and á2 macroglobulin were measured during the pre- and
post- relapse phase in three patients. Results: Fourteen occurrences of
relapse among 10 patients were confirmed during the study period. The A/G ratio
decreased to 0.10 ± 0.11 (mean ± SD), the increase in the mean percentage of á1 and á2 globulin fractions was statistically significant,
and analysis of three patient samples showed an increase in á1 acid glycoprotein (p = 0.04) and a decrease in
retinol binding protein (p = 0.04). Comparison of the A/G ratio with other
markers, ESR, SAA, and CRP, between the pre- and post- relapse phase showed
that all four factors changed significantly.
Conclusions: The A/G ratio appears to be a useful marker for relapsing
ocular Behçet’s disease.