Great Development in the military industry had been witnessed in the past two decades, especially in depleted uranium weapons. These weapons were first used by USA and its allies in 1991 in Iraq. Later they were used in Bosnia (1995), Kosovo and Serbia (1999) Afghanistan (2001) and finally Iraq (2003). The manufacturers and users of these weapons continued to blackout the nature of these weapons and deny the harm caused on the public health, animals and the environment. After a short period of time, facts were revealed by the investigations and research executed by large number of scientists and investigators. This paper highlights the important effects caused by the use of depleted uranium weapons on human health and environment.