The purpose of this study is to investigate the knowledge and attitudes of health professionals on the use of computers. Also objectives of this research are to compare the level of attitude towards the implementation and use of computer among the three groups of health professionals (doctors, nurses and administrative staff) and to investigate the factors that shape the attitude. The survey involved 300 Healthcare Professionals from the General Hospital in Laconia. For the collection of data used in the questionnaire Nurses Attitudes Toward Computerization (NATC) of Brodt & Stronge (1984). Medical and nursing staff had on average a lower average price than that of the administrative staff regarding the substantial contribution of Hospital Information Systems (HIS) in the provided quality care to the patient. The nurses had higher average price than that of the medical and administrative staff remained at the same level in the proposal that the use of computers reduces costs and workload. All Hospital Health Professionals averaged mean value at the same level as for the proposition that the use of computers as a danger to the loss of jobs and that is a threat to employment. Medical and nursing staff had on average a lower average price than that of the administrative staff regarding the use of computers offers more possibilities for the staff of the institution and increases efficiency. Finally, the average number of responses given by all health care professionals had an average mean at the same level as for the proposition that the use of computers increases legal liability of staff. Health professionals do not believe that the hospital will benefit from using the computer, they believe that the use of computer should not cause a loss of jobs, there is increasing legal liability of staff from using the computer, and showed that provide quality care to the patient and that there is an increase in profitability and staff possibilities of using the computer. Furthermore, the age, total years of working experience, the date of receiving diploma, computer knowledge, experience in the use of computers in general and at work and the total number of years of work are factors that influence the attitudes of health professionals towards computers.