The objective of this paper is to examine the impact of changes in extreme weather conditions and economic factors on freight transportation in Taiwan. To explore the effect of climate variability such as the increasing frequency and intensity of precipitation and typhoons, a climate-related freight prediction model using time series data is presented. Empirical results indicate that severe typhoons with extremely torrential rains show a significant influence on freight movements. In addition, the gross domestic product, changes in oil prices, and events of regional and global economic crises also significantly influence freight movements. Based on the findings of the analyses, some recommendations for reducing the vulnerability of freight sectors to climate change are proposed.